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Most specific biochemical reactions depend on molecules fitting closely together. This is why optical isomers are usually inactive, and why the key classes of molecules, such as the nucleic acids and the proteins, occur only in one hand. So to study function you must study the exact shape of biological molecules and their changes in shape. - Francis Crick, 2002
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Structural Biology Laboratory |
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Recent PublicationsAllendorph, G.P., Read, J.D., Kawakami, Y., Kelber, J.A., Isaacs, M.J., Choe, S. (2011) Designer TGF-beta superfamily ligands with diversified functionality PLoS One. 6, e26402. Farina, A.N., Blain, K.Y., Maruo, T., Kwiatkowski, W., Choe, S., Nakagawa, T. (2011) Sepearation of domain contacts is required for heterotetrameric assembly of functional NMDA receptors. J. Neurosci. 31, 3565-79. Balana, B., Maslennikov, I., Kwiatkowski, W., Stern, K.M., Bahima, L., Choe, S., Slesinger, P.A. (2011) Mechanism underlying selective regulation of G protein-gated inwardly rectifying potassium channels by the psychostimulant-sensitive sorting nexin 27. Proc. Natl. Acad. Sci. 108, 5831-6. View publication in:
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