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Most specific biochemical reactions depend on molecules fitting closely together. This is why optical isomers are usually inactive, and why the key classes of molecules, such as the nucleic acids and the proteins, occur only in one hand. So to study function you must study the exact shape of biological molecules and their changes in shape. - Francis Crick, 2002
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Structural Biology Laboratory |
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Recent PublicationsOu, H.D., Kwiatkowski, W., Deerinck, T., Noske, A., Blain, K.Y., Land, H., Soria, C., Powers, C.J., Shu, X., Tsien, R., Fitzpatrick, J.A.J., Long, J.A., Ellisman, M.H., Choe,S., O'Shea, C.C. (2012) Structure of E4-ORF3 reveals a viral supramolecular assembly that inactivates multiple tumor suppressors. Cell, 151, 304-19 [Cover]. Klammt C, Maslennikov I, Bayrhuber M, Eichmann C, Vajpai N, Chiu EJ, Blain KY, Esquivies L, Kwon JH, Balana B, Pieper U, Sali A, Slesinger PA, Kwiatkowski W, Riek R, Choe S. (2012) Facile backbone structure determination of human membrane proteins by NMR spectroscopy. Nat Methods. 9(8), 834-39. Keshwani MM, Klammt C, von Daake S, Ma Y, Kornev AP, Choe S, Insel PA, Taylor SS. (2012) Cotranslational cis-phosphorylation of the COOH-terminal tail is a key priming step in the maturation of cAMP-dependent protein kinase. Proc Natl Acad Sci U S A. 109(20), E1221-9. Epub 2012 Apr 9. View publication in:
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