TGF-Beta and GPCR Signaling

Yang, F., West, A.P. Jr., Allendorph. G.P., Choe, S., Bjorkman, P.J. (2008) Neogenin Interacts with Hemojuvelin through Its Two Membrane-Proximal Fibronectin Type III Domains. Biochemistry, 47, 4237-45.

Perrin, M.H., Grace, C.R., Digruccio, M.R., Fischer, W.H., Maji, S.K., Cantle, J.P., Smith, S., Manning, G., Vale, W.W., Riek, R. (2007) Distinct structural and functional roles of conserved residues in the first extracellular domain of receptors for corticotropin releasing factor and related G-protein coupled receptors. J.Biol.Chem., 282:37529-37536.

Grace CR, Perrin MH, Cantle JP, Vale WW, Rivier JE, Riek R. (2007) Common and divergent structural features of a series of corticotropin releasing factor-related peptides. J.Am.Chem.Soc. 129:16102-14.

Allendorph, G.P., Isaacs, M.J., Kawakami, Y., Belmonte, J.C., Choe, S. (2007) BMP-3 and BMP-6 Structures Illuminate the Nature of Binding Specificiy with Receptors. Biochemistry,46, 12238-12247.

Grace, C.R., Cervini, L., Gulyas, J., Rivier, J., Riek, R. (2007) Astressin-amide and astressin-acid are structurally different in dimethylsulfoxide. Biopolymers, 87, 196-205.

Blain, K.Y., Kwiatkowski, W., Zhao, Q., Fleur, D.L., Naik, C., Chun, T.W., Tsareva, T., Kanakaraj, P., Laird, M.W., Shah, R., George, L., Sanyal, I., Moore, P.A., Demeler, B., Choe, S. (2007) Structural and Functional Characterization of CC Chemokine CCL14. Biochemistry, 46, 10008-10015.

Grace, C.R., Perrin, M.H., Gulyas, J., Digruccio, M.R., Cantle, J.P., Rivier, J.E., Vale, W.W., Riek, R. (2007) Structure of the N-terminal domain of a type B1 G protein-coupled receptor in complex with a peptide ligand. Proc Natl Acad Sci U S A. 2007 104, 4858-63.

George Allendorph, Wylie Vale, Senyon Choe (2006) Structure of the ternary signaling complex of a TGF-beta superfamily member. Proc. Natl. Acad. Sci. 103, 7643-8.

Brown, M. A., Zhao, Q., Baker, K.A., Naik, C., Chen, C., Pukac, L., Singh, M., Tsareva, T., Parice, Y., Mahoney, A., Roschke, V., Sanyal, I., Choe, S. (2005) Crystal structure of BMP-9 and functional interactions with pro-region and receptors.. J. Biol. Chem., 280, 25111-8.

Grace, C.R., Perrin, M.H., DiGruccio, M.R., Miller, C.L., Rivier, J.E., Vale, W.W., Riek, R. (2004) NMR structure and peptide hormone binding site of the first extracellular domain of a type B1 G protein-coupled receptor. Proc Natl Acad Sci U S A. 2004 101,12836-41.

Greenwald J., Vega M.E., Allendorph G.P.,Fischer W.H., Vale W., Choe S. (2004) A flexible activin explains the membrane-dependent cooperative assembly of TGF-B family receptors. Molecular Cell, 15, 485-9.

Groppe J., Greenwald J., Wiater E., Rodriguez-Leon J., Economides AN., Kwiatkowski W., Baban K., Affolter M., Vale WW., Belmonte JC., Choe S. (2003) Structural basis of BMP signaling inhibition by Noggin, a novel twelve-membered cystine knot protein J.Bone & Joint Surgery 85, 52-58.

Greenwald, J.,  Groppe, J., Gray, P.,Wiater, E., Kwiatkowski, W., Vale, W., Choe, S. (2003) The BMP//ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly. Molecular Cell, 11, 605-617.

Groppe,J., Greenwald, J.,  Wiater, E., Rodriguez-Leon, J.,Economides, A., Kwiatkowski, W., Affolter, M., Vale, W., I.-Belmonte, J.-C., Choe, S. (2002) Structural basis of BMP signaling inhibition by Noggin, a novel cystine knot protein. Nature, 420,636-642.

Blanchoin, L., Robinson, R., Choe, S., Pollard, T. (2000) Phosphorylation of Acanth-amoeba actophorin (ADF/cofilin) blocks interaction with actin without structural change. J. Mol. Biol., 295, 203-211.

Wesche, J., Iedlocha, A., Falnes, P.O., Choe, S., Olsnes, S. (2000) Externally Added aFGF mutants do not require extensive unfolding for transport into the cytosol and the nucleus of NIH/3T3 cells. Biochemistry, 39, 15091-15100.

Robinson, R.C., Radziejewski, C., Spraggon, G., Greenwald, J., Kostura, M., Burtnick, L.D., Stuart, D.I., Choe, S., Jones, Y. (1999) The structures of the brain-derived neutrotrophic factor/neurotrophin 4 (NT4) heterodimer and the NT3 and NT4 homodimers reveal a common Trk-binding site. Protein Sci. , 8, 2589-2597.

Greenwald, J., Fischer, W., Vale, W.W., Choe, S. (1999) Three finger toxin fold for the extracellular ligand-binding domain of type II activin receptor serine kinase. Nature Struc. Biol., 6, 18-22.

Fischer, W., Greenwald, J., Park, M., Craig, A.G., Choe, S., Vale, W. (1999) The disulfide arrangement in the extracellular domain of the activin type II receptor. J. Protein Chemistry, 18, 437-46.

Robinson, R., Mejilano, M., Le, V., Burtnick, L.D., Yin, H.L., Choe, S. (1999) Domain movement in gelsolin: a Ca-activated switch. Science, 286, 1939-1942.

Ryan, A., Blumberg, B., Rodriguez-Estaban, C., Yonie-Tamura, S., Tamura, K., Tsukui, T., Peña, J., Sabbagh, W., Greenwald, J., Choe, S., Norris, D.P., Robertson, E.J., Evans, R.M., Rosenfeld, M.G., Belmonte, J. (1998) Pitx2 determines left-right asymmetry of internal organs in vertebrates. Nature 394, 545-51.

Greenwald, J., Le, V., Corrigan, A., Fischer, W., Komives, E., Vale, W., Choe, S. (1998) Characterization of the extracellular ligand-binding domain of the type II activin receptor serine kinase. Biochemistry, 37, 16711-8.