The following is a CLUSTAL W(1.60) multiple sequence alignment of the T1 domain of Shaker like channels.
Residue numbers are for alignment purpose. The sequence on the top (155764) is for Aplysia Shaker T1 ranging from Glu66 to Arg196. The numbering in the lineup is for sequence alignment purpose ONLY.
See also Shaw, Shab, and the Shal alignments. The colouring was done by Jalview a java based sequence alignment editor, with the following scheme:-
| Residues | Description | Colour |
| ILVAM | Aliphatic/hydrophobic residues | pink |
| FWY | Aromatic | orange |
| KRH | Positive | red |
| DE | Negative | green |
| STNQ | Hydrophilic | mid blue |
| PG | Proline/Glycine (conformationally special) | magenta |
| C | Cysteine | yellow |
