Publications

1)
Wider, G., Riek, R. and Wüthrich, K. (1996).
Diffusion filters for separation of solvent-protein and protein-protein nuclear overhauser effects (HYDRA).
J. Am. Chem. Soc. 118, 11629-11634.
 Article

2)
Riek, R., Hornemann, S., Wider, G., Billeter, M., Glockshuber, R. and Wüthrich, K. (1996).
NMR structure of the mouse prion protein domain PrP(121­231).
Nature 382, 180­182.
Abstract
 Article

3)
Glockshuber, R., Hornemann, S., Riek, R., Billeter, M., Wider, G. and Wüthrich, K. (1996).
Drei-dimensionale Struktur einer Domäne des zellulären Prion-Proteins aufgeklärt.
Spektrum der Wissenschaften9, 16­18.

4)
Wüthrich, K., Billeter, M., Güntert, P., Luginbühl, P., Riek, R. and Wider, G. (1996).
NMR studies of the hydration of biological macromolecules.
Faraday Discuss. 103, 245-253.

5)
Glockshuber, R., Hornemann, S., Riek, R., Wider, G., Billeter, M. and Wüthrich, K. (1997).
Autonomous folding and three-dimensional structure of the carboxy-terminal domain of the mouse prion protein, PrP(121-231).
Proceedings NATO advanced research workshop, in press.

6)
Billeter, M., Riek, R., Wider, G., Hornemann, S., Glockshuber, R. and Wüthrich, K. (1997).
Prion protein NMR structure and species barrier for prion diseases.
Proc. Natl. Acad. Sci. USA 94, 7281-7285.
Abstract
Article

7)
Glockshuber, R., Hornemann, S., Riek, R., Wider, G., Billeter, M. and Wüthrich, K. (1997).
Three-dimensional NMR structure of a self-folding domain of the prion protein, PrP(121-231).
Trends Biochem Sci. 22, 241-242.
 Article

8)
Hornemann, S., Korth, C., Oesch, B., Riek, R., Wider, M., Wüthrich, K. and Glockshuber, R. (1997).
Recombinant full-length murine prion protein, mPrP(23­231): Purification and spectroscopic characterization.
FEBS Letters 413, 277-281.
Abstract
Article

9)
Riek, R., Hornemann, S., Wider, G., Glockshuber, R. and Wüthrich, K. (1997).
NMR characterization of the full-length recombinant murine prion protein, mPrP(23­231).
FEBS Letters 413, 282-288.
Abstract

10)
Korth, C., Stierli, B., Streit, Moser, M., Schaller, O., Fischer, R., Schulz-Schaefer, W., Kretzschmar, H., Raeber, A., Braun, U., Ehrensperger, F., Hornemann, S., Glockshuber, R., Riek, R., Billeter, M., Wüthrich, K. and Oesch, B. (1997).
Prion (PrPSc)-specific epitope defined by a monoclonal antibody.
Nature 390 , 74-77.
Abstract

11)
Pervushin, K., Riek, R., Wider, G. and Wüthrich, K. (1997).
Attenuated T2 relaxation by mutual cancellation of dipole-dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution.
Proc. Natl. Acad. Sci. USA  94, 12366-12371.
Abstract
Article

12)
Glockshuber, R., Hornemann, S., Billeter, M., Riek, R., Wider, G., Wüthrich, K. (1998).
Prion protein structural features indicate possible relations to signal peptidases.
FEBS Letters 426, 291-296.
Abstract
Article

13)
Pervushin K., Riek, R., Wider, G., Wüthrich, K. (1998). Transverse Relaxation-Optimized Spectroscopy (TROSY) for NMR studies of aromatic spin systems in 13C-labeled proteins.
J. Am. Chem. Soc.  120, 6394-6400.
Article

14)
Riek, R., Wider, Billeter, M., Hornemann, S., G., Glockshuber, R. and Wüthrich, K. (1998).
Prion protein NMR structure and familial human spongiform encephalopathies.
Proc. Natl. Acad. Sci. USA95, 11667-11672.
Abstract
Article

15)
Glockshuber, R., Hornemann, S., Riek, R., Billeter, M., Wider, G., Liemann, S., Zahn, R. and Wüthrich, K. (1998).
Folding and Three-Dimensional NMR Structure of the Recombinant Cellular Prion Protein from the Mouse.
In PRIONS - Molecular and Cellular Biology (D. A. Harris, ed.), Horizon Scientific Press, pp. 1-25.

16)
Riek,R., Wider, G., Pervushin, K.  and Wüthrich, K. (1999).
Polarization transfer by cross-correlated relaxation in  solution NMR with very large  molecules.
Proc. Natl. Acad. Sci. USA  96, 4918-4923.
Abstract
Article

17)
Wüthrich, K. Billeter, M., Riek, R., Wider, G., Hornemann, S. and Glockshuber, R. (1999). Prion protein structure and pathology of transmissible spongiform encephalopathies in: Peptide Science - Present and Future  (Y. Shimonishi, ed.), Kluwer, Dordrecht, pp. 330-334.
 Article

18)
Pervushin, K., Wider, G., Riek, R. and Wüthrich, K. (1999).
The 3D NOESY-[1H,15N,1H]-ZQ-TROSY NMR experiment with diagonal peak suppression.
Proc. Natl. Acad. Sci. USA  96, 9607-9612.
Abstract
Article

19)
Liu, A., Riek, R., Zahn, R., Hornemann, S., Glockshuber, R. and Wüthrich, K. (1999).
Peptides and proteins in neurodegenerative disease: helix propensitiy of a polypeptide containing helix 1 of the mouse prion protein studied by NMR and CD spectroscopy.
Biopolymers  51, 145-152.
Abstract

20)
Riek, R.,  Precheur, B., Wang, Y., Mackay, E.A., Wider, G., Guntert, P., Liu., A., Kagi, J.H.R.  and Wüthrich, K. (1999).
NMR structure of the sea urchin (Strongylocentrotus purpuratus) metallothionein MTA.
J. Mol. Biol.  291, 417-428.
Abstract
Article

21)
Wüthrich, K. , Riek, R.,  Wider, G.,  Garcia, F.L., Liu.,  A., Zahn, R., Hornemann, S.  and Glockshuber, R. (1999).
Structural biology of prion proteins.
Transfusion clinique et biologique  6, 31.

22)
Zahn, R., Liu, A., Luehrs, T., Riek, R., von Schroetter, C., Garcia, F.L., Billeter, M., Calzolai, L., Wider, G. and Wüthrich, K. (2000).
NMR solution structure of the human prion protein.
Proc. Natl. Acad. Sci. USA 97, 145-150.
Abstract
Article

23)
Pervushin, K., Fernandez, C., Riek, R., Ono, A., Kainosho, M. and Wüthrich, K. (2000).
Determination of (h2)J(NN) and (h1)J(HN) coupling constants across Watson-Crick base pairs in the Antennapedia homeodomain-DNA complex using TROSY.
J. Biomol. NMR 16, 39-46.
Abstract
Article

24)
Liu, A., Riek, R.,  Wider, G., von Schroetter C., Zahn, R. and Wüthrich, K. (2000).
NMR experiments for resonance assignments of C-13, N-15 doubly-labeled flexible polypeptides: Application to the human prion protein hPrP(23-230).
J. Biomol. NMR 16, 127-138.
Abstract
Article

25)
Lopez-Garcia, F., Zahn, R., Riek, R. and Wüthrich, K. (2000).
NMR  structure of the bovine prion protein.
Proc. Natl. Acad. Sci. USA 97, 8334-8339.
Abstract
Article

26)
Calzolai, L., Lysek, D. A., Guentert, P., von Schroetter, C., Riek, R., Zahn, R.  and Wüthrich, K. (2000).
NMR structures of three single-residue variants of the human prion protein.
Proc. Natl. Acad. Sci. USA 97, 8340-8345.
Abstract
Article

27)
Riek, R., Pervushin, K.  and Wüthrich, K. (2000).
TROSY and CRINEPT:NMR with large molecular and supramolecular structures in solution.
TiBS 25, 462-468.
Abstract
Article

28)
Riek, R., Pervushin, K., Fernandez, C., Kainosho, M.  and Wüthrich, K. (2001).
[13C,13C]- and [13C,1H]-TROSY in a triple resonance experiment for ribose-base and intrabase correlations in nucleic acids.
J. of Am. Chem. Soc.  123, 658-664.
Abstract
Article
 

29)
Ellgaard, L., Riek, R., Braun, D., Herrmann, T., Helenius, A., and Wüthrich, K. (2001).
Three-dimensional structure topology of the calretiuclin P-domain based on NMR assignment
FEBS Lett.  488, 69-73.
Abstract
Article

30)
Riek, R. (2001).
Characterization of Hydrogen Bond Lengths in Watson-Crick Base pairs by Cross-correlated Relaxation
J. of Magn. Reson.  149, 149-153.
Abstract
Article

31)
Wüthrich, K. and Riek, R. (2001).
Three-dimensional structures of prion proteins
Adv. in Prot. Chem.  57, 55-82.

32)
Ellgaard, L., Riek, R., Guentert, P,  Herrmann, T., Helenius, A., and Wüthrich, K. (2001).
NMR structure of the calreticulin P-domain
Proc. Natl. Acad. Sci. USA 98, 3133-3138.
Abstract
Article

33)
Riek, R. (2001)
Enhancement of the steady-state magnetization in TROSY experiments
J. Biomol. NMR 21, 99-105.
Article

34)
Riek, R., Guntert, P., Dobeli, H., Wipf,  B., and Wutrhich, K. (2001)
NMR studies in aqueous solution fail to identify significant conformational differences between the monomeric forms of two Alzheimer peptides with widely different plaque-competence, Abeta(1-40)ox and Abeta(1-42)ox.
Eur. J. Biochem 268, 5930-5936.
Abstract
Article

35)
Frickel, E.M., Riek, R., Jelesarov, I. Helenius, A., Wutrhich, K. and Ellgaard, L. (2002)
TROSY-NMR reveals interaction between ERp57 and the tip of the calretiuclin P-domain.
Proc. Natl. Acad. Sci. USA 99, 19544-1959.
Abstract
Article

36)
Riek, R., Fiaux, J., Bertlesen, E.B., Horwich, A.L. and Wuthrich, K. (2002)
Solution NMR techniques for large molecular and supramolecular structures.
J. Am. Chem. Soc. 124, 12144-12153.
Abstract
Article

37)
Riek, R. (2002)
TROSY: Transverse Relaxation-Optimized Spectroscopy
in BioNMR in Drug Research (ed. Oliver Zerbe)
Methods and Principles in Medicinal Chemistry 16, 227-241, Wiley-VCH, Weinheim (Germany).
Article

38)
Luhrs, T., Riek, R., Guntert,  P. and Wuthrich, K. (2003)
NMR structure of the Human Doppel Protein.
J. Mol. Biol. 326, 1549-1557.
Abstract
Article

39)
Kwiatkowski, W. and Riek, R. (2003)
Chemical shift-dependent apparent scalar couplings: An alternative concept of chemical shift monitoring in multi-dimensional NMR experiments.
J. Biomol. NMR 25, 281-290.
Abstract
Article

40)
Riek, R. and Luhrs,  T. (2003)
Three-dimensional structures of the prion protein and its doppel
Clin. Lab. Med. 23, 209-225.
Abstract
Article

41)
Balguerie, A., Dos Reis, S., Ritter, C., Chaignepain,  S., Coulary-Salin, B., Forge, V., Bathany, K., Lascu, I., Schmitter, J.M., Riek, R. and Saupe S.J. (2003)
Domain organization and structure-function relationship of the HET-s prion protein of Podospora anserina.
EMBO J. 22, 2071-2081.
Abstract
Article

42)
Grace, C.R.R., Koerber, S. C., Erchegyi, J., Reubi, J.C., Rivier, J. and Riek, R. (2003)
Novel sst4-selective Somatostatin (SRIF) Agonists. 4. Three-Dimensional Consensus structure by NMR.
J. Med. Chem. 18, 5606-5618.
Article

43)
Grace, C.R.R. and Riek, R. (2003)
Pseudomultidimensional NMR by Spin-state Selective Off-Resonance Decoupling
J. Am. Chem. Soc. 125, 16104-16113.
Article

44)
Pegan, S., Kwiatkowski, W., Choe, S and Riek, R. (2003)
High-throughput backbone resonance assignment of small 13C,15N-labeled proteins by a triple-resonance experiment with four sequential connectivity pathways using chemical shift-dependent, apparent 1J(1H,13C): HNCACBcodedHAHB
J. Magn. Reson. 165, 315-319.
Article

45)
Ritter, C., Luhrs, T., Kwiatkwoski W. and Riek, R. (2004)
3D TROSY-HNCAcodedCB and TROSY-HNCAcodedCO experiments: Triple resonance experiments with two sequential connectivity pathways and high sensitivity.
J. Biomol NMR. 28, 289-294.
Article
 
 46)
Grace, C.R., Perrin, M.H., DiGruccio, M.R. Miller, C.L., Rivier, J.E. Vale, W.W., Riek, R. (2004)
NMR structure and peptide hormone binding site of the first extracellular domain of a type B1 G protein-coupled receptor. Proc. Natl. Acad. Sci. USA, 101, 12836-12841
.
Article

47)
Grace, C.R., Durrer, L., Koerber, S.C., Erchegyi, J., Reubi, J.C., Rivier, J., Riek, R. (2005) , Somatostatin Receptor 1 Selective Analogs: 4. Three-Dimensional Consensus Structure by NMR. J. Med. Chem. 48, 523-533.
Article

48)
Siemer, A.B., Ritter, C., Ernst, M. Riek, R., Meier B.H. (2005) High-Resolution Solid-State NMR Spectroscopy of the Prion Protein HET-s in Its amyloid conformation. Angewandte Chemie International 44, 2441-2444.
Article

49)
Roosild, T.P., Greenwald, J. Vega, M. Castronovo, S., Riek R., Choe, S. (2005) NMR structure of Mistic, a membrane integrating protein for membrane protein expression. Science, 307, 1317-1321.
Article
Supplementary Material 

50)
Verdecia, M.A., Larkin, R.M., Ferrer, J.-L., Riek, R., Chory, J., Noel, J.P. (2005) Structure of the Mg-Chelatase Cofactor GUN4 reveals a Novel hand-Shaped fold for Porphyirin Binding, PLos Biology, 3, e151-e164
Article

51)
Ritter, C., Maddelein, M.L., Siemer, A.B. Luhrs, T., Ernst, M., Meier, B.H., Saupe, S.J., Riek, R. (2005) Correlation of structural elements and infectivity of the HET-s prion. Nature, 435, 844-848.
Article
Supplementary Material

52)
Luhrs, T., Ritter, C., Adrian, M., Riek-Loher, D., bohrmann, B., Doebeli, H., Schubert, D., Riek, R. (2005) 3D structure of Alzheimer's amyloid-beta(1-42) fibrils. Proc. Natl. Acad. Sci. 102, 17342-17347.
Article
Supplementary Material

53)
Siemer, A.B., Ritter, C., Steinmetz, M.O., Ernst, M., Riek, R., Meier, B.H. (2006) 13C,15N resonance assignment of pHET-s(218-289). J. Biomol. NMR, 34, 75-87.
Article

54)
Tzakos, A.G., Grace, C.R., Lukavsky, P.J., Riek, R. (2006) NMR techniques for very large proteins and RNAs in solution. Annu. Rev. Biophys. Biomol. Struct. 35, 319-342.
Article

55)
Keller, R., Grace, C.R., Riek, R. (2006) Fast multidimensional NMR spectroscopy by spin state-selective off-resonance decoupling (SITAR). Magn. Reson. Chem. 44, S196-205.
Article
Supplementary Material

56)
Grace, C.R., Erchegyi, J., Koerber, S.C., Reubi, J.C., Rivier, J. Riek, R. (2006) Novel sst2-selective somatostatin agonists. Three-dimensional consensus structure by NMR. J. Med. Chem. 49, 4487-4496.
Article

57)
Perrin, M.H, Grace, C.R., Riek, R., Vale, W.W. (2006) The three-dimensional structure of the N-terminal domain of a corticotropin releasing factor receptor: sushi domains and the B1 family of G protein-coupled receptors. Ann N.Y. Acad. Sci. 1070:105-119.
Article


58)
Liu, Y., Ritter, C., Riek, R. Schubert, D. (2006) The formation of bioactive amyloid speceis by prion proteins in vitro and in cells.  Neurosci. Lett., 406, 200-204.
Article

 59)
Siemer, A.B., Arnold, A.A., Ritter, C., Westfeld, T., Ernst, M., Riek, R., Meier, B.H. (2006) Observation of Highly Flexible Residues in Amyloid Fibrils of the HET-s prion. J. Am. Chem. Soc., 128, 13224-13228.
Article

 

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